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| Symbol | DYNLRB1 |
| Full Name | Dynein Light Chain Roadblock Type 1 |
| Chromosome | 12q24.31 |
| NCBI Gene | 54602 |
| OMIM | 607207 |
| Ensembl | ENSG00000125970 |
| UniProt | Q9NPJ3 |
| Associated Diseases | Neurodevelopmental disorders (potential) |
DYNLRB1 (Dynein Light Chain Roadblock 1) is a component of the cytoplasmic dynein complex that mediates retrograde axonal transport in neurons. As a light chain subunit, DYNLRB1 (Dynein Light Chain Roadblock 1) plays critical roles in transporting cargoes along microtubules, including synaptic vesicles, organelles, and signaling complexes. Dysregulated DYNLRB1 (Dynein Light Chain Roadblock 1) function has been implicated in neurodegenerative diseases including Alzheimer's disease and Charcot-Marie-Tooth disease.
DYNLRB1 is a dynein light chain that contributes to the dynein complex. It participates in retrograde transport in neurons and may be involved in synaptic function.
Expressed in neurons, especially in hippocampus.