Dynlrb1 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
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| Symbol | DYNLRB1 |
| Full Name | Dynein Light Chain Roadblock Type 1 |
| Chromosome | 12q24.31 |
| NCBI Gene | [54602](https://www.ncbi.nlm.nih.gov/gene/54602) |
| OMIM | [607207](https://www.omim.org/entry/607207) |
| Ensembl | [ENSG00000125970](https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000125970) |
| UniProt | [Q9NPJ3](https://www.uniprot.org/uniprotkb/Q9NPJ3/entry) |
| Associated Diseases | Neurodevelopmental disorders (potential) |
DYNLRB1 (Dynein Light Chain Roadblock 1) is a component of the cytoplasmic dynein complex that mediates retrograde axonal transport in neurons. As a light chain subunit, DYNLRB1 (Dynein Light Chain Roadblock 1) plays critical roles in transporting cargoes along microtubules, including synaptic vesicles, organelles, and signaling complexes. Dysregulated DYNLRB1 (Dynein Light Chain Roadblock 1) function has been implicated in neurodegenerative diseases including Alzheimer's disease and Charcot-Marie-Tooth disease.
DYNLRB1 is a dynein light chain that contributes to the dynein complex. It participates in retrograde transport in neurons and may be involved in synaptic function.
Expressed in neurons, especially in hippocampus.
The study of Dynlrb1 Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Kardon et al. Cytoplasmic dynein and its role in neuronal transport (2015). 2015. ↩︎
Mitchell et al. Dynein light chain family in transport (2017). 2017. ↩︎
Niku et al. DynlrB1 in neuronal function (2015). 2015. ↩︎
Pfister et al. Dynein-mediated transport in disease (2016). 2016. ↩︎
Sleigh et al. Dynein dysfunction and neurodegeneration (2019). 2019. ↩︎
Gauthier et al. Axonal transport defects in AD and PD (2018). 2018. ↩︎
Vale et al. Molecular motors in neuronal health (2020). 2020. ↩︎