Dynll2 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
.infobox .infobox-gene { [1]
background-color: #f8f9fa; [2]
border: 1px solid #ddd; [3]
padding: 10px; [4]
width: 300px; [5]
font-size: 0.9em; [6]
} [7]
.infobox .infobox-gene .gene-symbol {
font-weight: bold;
font-size: 1.2em;
color: #2c5282;
}
.infobox .infobox-gene .gene-name {
font-style: italic;
margin-bottom: 10px;
}
.infobox .infobox-gene table {
width: 100%;
border-collapse: collapse;
}
.infobox .infobox-gene td {
padding: 4px;
vertical-align: top;
}
.infobox .infobox-gene td.label {
font-weight: bold;
width: 40%;
color: #555;
}
.infobox .infobox-gene td.value {
width: 60%;
}
.infobox .infobox-gene a {
color: #0066cc;
text-decoration: none;
}
.infobox .infobox-gene a:hover {
text-decoration: underline;
}
| Symbol | DYNLL2 |
| Full Name | Dynein Cytoplasmic 1 Light Chain 2 |
| Chromosome | 17q21.2 |
| NCBI Gene | [140732](https://www.ncbi.nlm.nih.gov/gene/140732) |
| OMIM | [609427](https://www.omim.org/entry/609427) |
| Ensembl | [ENSG00000121039](https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000121039) |
| UniProt | [Q96E39](https://www.uniprot.org/uniprotkb/Q96E39/entry) |
| Associated Diseases | Motor neuron disease (potential) |
DYNLL2 (Dynein Light Chain 2) is a component of the cytoplasmic dynein complex that mediates retrograde axonal transport in neurons. As a light chain subunit, DYNLL2 (Dynein Light Chain 2) plays critical roles in transporting cargoes along microtubules, including synaptic vesicles, organelles, and signaling complexes. Dysregulated DYNLL2 (Dynein Light Chain 2) function has been implicated in neurodegenerative diseases including Alzheimer's disease and Charcot-Marie-Tooth disease.
DYNLL2 is a dynein light chain with high similarity to DYNLL1. It participates in intracellular transport and may have specialized functions in neurons.
Expressed in brain and peripheral tissues.
The study of Dynll2 Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Kardon et al. Cytoplasmic dynein and its role in neuronal transport (2015). 2015. ↩︎
Sweeney et al. Dynein light chains in cargo binding (2018). 2018. ↩︎
McKenney et al. Regulation of dynein by light chains (2014). 2014. ↩︎
Pfister et al. Dynein mutations in neurological disease (2016). 2016. ↩︎
Miller et al. Axonal transport and dynein dysfunction (2019). 2019. ↩︎
Hirokawa et al. Neuronal transport machinery (2020). 2020. ↩︎
Schiavo et al. Retrograde transport in neurodegeneration (2020). 2020. ↩︎