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| Symbol | DYNLL2 |
| Full Name | Dynein Cytoplasmic 1 Light Chain 2 |
| Chromosome | 17q21.2 |
| NCBI Gene | 140732 |
| OMIM | 609427 |
| Ensembl | ENSG00000121039 |
| UniProt | Q96E39 |
| Associated Diseases | Motor neuron disease (potential) |
DYNLL2 (Dynein Light Chain 2) is a component of the cytoplasmic dynein complex that mediates retrograde axonal transport in neurons. As a light chain subunit, DYNLL2 (Dynein Light Chain 2) plays critical roles in transporting cargoes along microtubules, including synaptic vesicles, organelles, and signaling complexes. Dysregulated DYNLL2 (Dynein Light Chain 2) function has been implicated in neurodegenerative diseases including Alzheimer's disease and Charcot-Marie-Tooth disease.
DYNLL2 is a dynein light chain with high similarity to DYNLL1. It participates in intracellular transport and may have specialized functions in neurons.
Expressed in brain and peripheral tissues.