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| Symbol | DYNLL1 |
| Full Name | Dynein Cytoplasmic 1 Light Chain 1 |
| Chromosome | 12q12 |
| NCBI Gene | 8655 |
| OMIM | 601280 |
| Ensembl | ENSG00000101290 |
| UniProt | P63167 |
| Associated Diseases | Alzheimer's disease, Charcot-Marie-Tooth disease |
DYNLL1 (Dynein Light Chain 1) is a component of the cytoplasmic dynein complex that mediates retrograde axonal transport in neurons. As a light chain subunit, DYNLL1 (Dynein Light Chain 1) plays critical roles in transporting cargoes along microtubules, including synaptic vesicles, organelles, and signaling complexes. Dysregulated DYNLL1 (Dynein Light Chain 1) function has been implicated in neurodegenerative diseases including Alzheimer's disease and Charcot-Marie-Tooth disease.
DYNLL1 is a component of the dynein motor complex, essential for retrograde axonal transport. It binds to numerous neuronal proteins and is implicated in neurodegenerative processes when transport is impaired.
High expression in neurons throughout the brain.