Dynll1 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
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| Symbol | DYNLL1 |
| Full Name | Dynein Cytoplasmic 1 Light Chain 1 |
| Chromosome | 12q12 |
| NCBI Gene | [8655](https://www.ncbi.nlm.nih.gov/gene/8655) |
| OMIM | [601280](https://www.omim.org/entry/601280) |
| Ensembl | [ENSG00000101290](https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000101290) |
| UniProt | [P63167](https://www.uniprot.org/uniprotkb/P63167/entry) |
| Associated Diseases | [Alzheimer's disease](/diseases/alzheimers-disease), Charcot-Marie-Tooth disease |
DYNLL1 (Dynein Light Chain 1) is a component of the cytoplasmic dynein complex that mediates retrograde axonal transport in neurons. As a light chain subunit, DYNLL1 (Dynein Light Chain 1) plays critical roles in transporting cargoes along microtubules, including synaptic vesicles, organelles, and signaling complexes. Dysregulated DYNLL1 (Dynein Light Chain 1) function has been implicated in neurodegenerative diseases including Alzheimer's disease and Charcot-Marie-Tooth disease.
DYNLL1 is a component of the dynein motor complex, essential for retrograde axonal transport. It binds to numerous neuronal proteins and is implicated in neurodegenerative processes when transport is impaired.
High expression in neurons throughout the brain.
The study of Dynll1 Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Kardon et al. Cytoplasmic dynein and its role in neuronal transport (2015). 2015. ↩︎
Roberts et al. Dynactin and dynein in axonal transport (2018). 2018. ↩︎
McKenney et al. Activation of cytoplasmic dynein (2014). 2014. ↩︎
Pfister et al. Genetic defects in dynein and neurodegeneration (2016). 2016. ↩︎
Sleigh et al. Dynein-mediated transport in neuronal disease (2019). 2019. ↩︎
Gauthier et al. Axonal transport defects in neurodegeneration (2018). 2018. ↩︎
Schiavo et al. Retrograde signaling in neuronal degeneration (2020). 2020. ↩︎