DUSP14 (Dual Specificity Phosphatase 14), also known as MKP-L, is a member of the dual-specificity phosphatase (DUSP) family. These enzymes regulate MAP kinase signaling pathways by dephosphorylating both tyrosine and threonine residues, playing critical roles in cellular signaling, stress responses, and inflammation.
| Property | Value |
|---|---|
| Gene Symbol | DUSP14 |
| Gene Name | Dual Specificity Phosphatase 14 |
| Aliases | MKP-L, CL100, JSP1 |
| Chromosomal Location | 17p12 |
| NCBI Gene ID | 11072 |
| OMIM | 610007 |
| UniProt | Q9Y263 |
| Ensembl | ENSG00000156345 |
DUSP14 encodes a dual-specificity phosphatase that regulates MAP kinase signaling:
DUSP14 dephosphorylates and inactivates:
DUSP14 is expressed in various tissues:
DUSP14 modulates cellular responses to stress:
Regulates apoptosis and cell cycle progression through MAP kinase pathways.
DUSP14 dysregulation is associated with:
Potential roles in:
DUSP14 is a dual-specificity phosphatase regulating MAP kinase signaling with roles in stress responses and cell survival.