| Full Name | Dynamin 1-Like Protein |
|---|---|
| Chromosomal Location | 12p11.21 |
| NCBI Gene ID | 10065 |
| OMIM | 603850 |
| Ensembl ID | ENSG00000141971 |
| UniProt | O00429 |
| Associated Diseases | Alzheimer's Disease, Parkinson's Disease, Huntington's Disease, Optic Atrophy |
DRP1 (Dynamin 1-Like Protein), encoded by the DNM1L gene, is a key mediator of mitochondrial fission and peroxisomal division[1]. It is essential for mitochondrial dynamics and its dysfunction is implicated in major neurodegenerative diseases[2].
The DRP1 gene encodes a 736-amino acid GTPase:
DRP1 is ubiquitously expressed:
The study of Drp1 Gene Dynamin 1 Like Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Bossy B, et al. Dynamin-related protein 1 in mitochondrial dynamics and neurodegeneration. Journal of Neuroscience. 2010;30(22):7392-7400. doi:10.1523/JNEUROSCI.0117-10.2010. ↩︎
Wang W, et al. Mitochondrial fission and fusion in neurodegenerative diseases. Brain Research. 2019;1702:39-48. doi:10.1016/j.brainres.2018.03.016. ↩︎
Kageyama Y, et al. Mitochondrial dynamics in neurodegeneration. Trends in Cell Biology. 2012;22(2):76-84. doi:10.1016/j.tcb.2011.11.002. ↩︎