| DRD1 — Dopamine Receptor D1 | |
|---|---|
| Symbol | DRD1 |
| Full Name | Dopamine Receptor D1 |
| Chromosome | 5q35.2 |
| NCBI Gene | 1817 |
| Ensembl | ENSG00000184845 |
| UniProt | P21709 |
| Diseases | Parkinson's Disease, Schizophrenia, Huntington's Disease |
| Expression | Striatum, Cortex, Nucleus accumbens, Olfactory bulb |
Drd1 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
DRD1 (Dopamine Receptor D1) encodes the D1 dopamine receptor, a G protein-coupled receptor that stimulates adenylyl cyclase and increases intracellular cAMP. It is the most abundant dopamine receptor in the striatum and plays critical roles in motor control, reward, and cognition[1].
The D1 receptor is a postsynaptic dopamine receptor that:
| Drug Class | Examples | Indication |
|---|---|---|
| D1 agonists | Aplindore, PF-06412562 | PD, Restless legs |
| D1 partial agonists | Sumarampion | Potential cognitive enhancer |
The study of Drd1 Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Missale C, Nash SR, Robinson SW, et al. Dopamine receptors: from structure to function. Physiol Rev. 1998;78(1):189-225. PMID:9457173 ↩︎