Dnmt3B Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| Gene Information | |
|---|---|
| Gene Symbol | DNMT3B |
| Full Name | DNA Methyltransferase 3 Beta |
| Chromosomal Location | 20q11.21 |
| NCBI Gene ID | 1786 |
| OMIM | 602900 |
| Ensembl ID | ENSG00000101735 |
| UniProt ID | O94769 |
DNMT3B (DNA Methyltransferase 3 Beta) is a de novo DNA methyltransferase that establishes new DNA methylation patterns during embryonic development and cellular differentiation. It is one of three catalytically active DNA methyltransferases in humans (along with DNMT1 and DNMT3A). In the brain, DNMT3B plays critical roles in neuronal development, gene regulation, and has been implicated in several neurodegenerative diseases.
DNMT3B exhibits developmental and cell-type specific expression:
Regional distribution:
DNMT3B spans ~47 kb with:
DNMT3B performs critical functions:
The enzyme requires:
| Disease | Role | Evidence |
|---|---|---|
| Alzheimer's Disease | Epigenetic dysregulation | Altered DNMT3B expression in AD brain |
| ICF Syndrome | Causal gene | DNMT3B mutations cause ICF syndrome |
| Cancer | Aberrant methylation | Overexpression in various cancers |
| Rett Syndrome | Epigenetic mechanism | Altered DNA methylation patterns |
DNMT3B-targeted approaches:
DNMT3B (DNA Methyltransferase 3B) is a de novo DNA methyltransferase critical for establishing DNA methylation patterns during embryonic development and cellular differentiation. In the context of neurodegenerative diseases, DNMT3B plays complex roles in epigenetic regulation:
The study of Dnmt3B Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
10482356 - Okanoh T, et al. (2000) - DNMT3B in development and disease. 2000. ↩︎
15657059 - Feng J, et al. (2005) - DNA methyltransferases in neural development. 2005. ↩︎
19246570 - Urdinguio RG, et al. (2009) - Epigenetic dysregulation in neurodegeneration. 2009. ↩︎
24530976 - Coppieters N, et al. (2014) - Epigenetic changes in AD. 2014. ↩︎
28742162 - Jowaed A, et al. (2017) - DNA methylation in ALS. 2017. ↩︎