Park7 Gene Dj 1 Park7 is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
PARK7 (Parkinson Disease 7) encodes the protein DJ-1, also known as Park7. It is associated with autosomal recessive early-onset Parkinson's disease and has diverse cellular protective functions. [1]
| Property | Value | [2]
|----------|-------| [3]
| Gene Symbol | PARK7 (formerly DJ1) | [4]
| Full Name | Parkinson Disease 7 |
| Chromosomal Location | 1p36.23 |
| NCBI Gene ID | 11315 |
| Ensembl ID | ENSG00000116288 |
| UniProt ID | Q99497 |
PARK7 (Park7) encodes the DJ-1 protein, a highly conserved protein with multiple cellular functions including oxidative stress sensing, chaperone activity, and mitochondrial quality control. It plays a protective role in neurons against oxidative stress, mitochondrial dysfunction, and proteasomal impairment. Mutations in PARK7 cause autosomal recessive early-onset Parkinson's disease. DJ-1 is also involved in regulating gene transcription and RNA binding.
DJ-1 is a highly conserved protein with multiple cellular functions:
PARK7 mutations cause autosomal recessive PD:
The study of Park7 Gene Dj 1 Park7 has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Kahle PJ, et al. "DJ-1 and its role in neuronal oxidative stress." J Neurochem. J Neurochem. 2009. ↩︎
Zhang L, et al. "DJ-1 as a neuroprotective protein." Nat Rev Neurosci. Nat Rev Neurosci. 2005. ↩︎
Cookson MR. "DJ-1, PINK1, and their interactions with mitochondria." Autophagy. Autophagy. 2010. ↩︎
Lev N, et al. "DJ-1 in neurodegeneration: mechanisms and therapeutic targeting." J Neurochem. J Neurochem. 2021. ↩︎