Cxcr4 C X C Motif Chemokine Receptor 4 plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
Cxcr4 C X C Motif Chemokine Receptor 4 is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| C-X-C Motif Chemokine Receptor 4 | |
|---|---|
| Gene Symbol | CXCR4 |
| Full Name | C-X-C Motif Chemokine Receptor 4 |
| Chromosome | 2q22.1 |
| NCBI Gene ID | 7852 |
| OMIM | 162643 |
| Ensembl ID | ENSG00000121966 |
| UniProt ID | P61073 |
| Associated Diseases | Alzheimer's Disease, Parkinson's Disease, WHIM Syndrome, Cancer |
CXCR4 is a G protein-coupled receptor for CXCL12 (SDF-1). It is essential for brain development, neural stem cell migration, and cell survival. It is also the co-receptor for HIV entry in some cell types[^1].
CXCR4 is a CXC chemokine receptor:
CXCR4 performs essential functions:
CXCR4 is implicated in AD:
In PD:
CXCR4 mutations cause WHIM:
CXCR4 is expressed in:
In the brain, CXCR4 is expressed on neural stem cells and neurons.
Cxcr4 C X C Motif Chemokine Receptor 4 plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
The study of Cxcr4 C X C Motif Chemokine Receptor 4 has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.