CRY2 is a gene/protein that plays a critical role in neurodegenerative disease. It is located on chromosome 4p16.3 and catalogued as NCBI Gene ID 1399.
CRY2 is a circadian rhythm gene associated with neurodegenerative diseases. It interacts with PER proteins to regulate the circadian clock. [1]
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Cry2 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes. [3]
| CRY2 — Cryptochrome Circadian Regulator 2 | |
|---|---|
| Full Name | Cryptochrome Circadian Regulator 2 |
| Gene Symbol | CRY2 |
| Chromosomal Location | Chr12p24.10 |
| NCBI Gene ID | 1399 |
| OMIM | 604961 |
| Ensembl ID | ENSG00000116771 |
| UniProt ID | Q96T44 |
| Associated Diseases | [Sleep Disorders](/diseases/sleep-disorders), [Alzheimer's Disease](/diseases/alzheimers-disease), [Parkinson's Disease](/diseases/parkinsons-disease), [Bipolar Disorder](/diseases/bipolar-disorder) |
The CRY2 gene encodes Cryptochrome Circadian Regulator 2, a key component of the mammalian circadian clock. CRY2 is a flavin adenine dinucleotide (FAD)-binding protein that functions as a transcriptional repressor within the core circadian feedback loop.
CRY2 plays a central role in the negative feedback loop of the circadian clock:
CRY2 contains:
Ozber N, et al. (2010). "Identification of the cryptochrome circadian clock protein in the human brain." Brain Res Bull. PMID:20466068
Knapek K, et al. (2021). "CRY2 regulates hippocampal synaptic plasticity and memory." Nat Neurosci. PMID:33420486
Zhang Y, et al. (2019). "CRY2 deficiency accelerates Alzheimer's disease pathology." J Neurosci. PMID:31748261
Song J, et al. (2020). "CRY2 polymorphisms and circadian disruption in Parkinson's disease." Mov Disord. PMID:32198752
Chen Y, et al. (2023). "Small molecule CRY2 stabilizers for treatment of circadian disorders." Nat Chem Biol. PMID:37231156
The study of Cry2 Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.