Cox7A1 Cytochrome C Oxidase Subunit plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
Cox7A1 Cytochrome C Oxidase Subunit is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes. [1]
| Attribute | Value | [2]
|-----------|-------| [3]
| Gene Symbol | COX7A1 | [4]
| Full Name | Cytochrome C Oxidase Subunit VIIa Polypeptide 1 | [5]
| Chromosomal Location | 19q13.12 | [6]
| NCBI Gene ID | 997 | [7]
| Ensembl ID | ENSG00000127838 |
| UniProt ID | P24310 |
| Associated Diseases | Mitochondrial complex IV deficiency, Leigh syndrome, Neurodegeneration |
COX7A1 encodes a subunit of cytochrome c oxidase (Complex IV) of the mitochondrial respiratory chain. This protein is part of the COX7a family and is specifically expressed in skeletal muscle and heart tissue.
Mutations in COX7A1 can lead to mitochondrial complex IV deficiency, causing:
Mitochondrial dysfunction is a hallmark of neurodegeneration:
COX7A1 has tissue-specific expression:
Cytochrome c oxidase (COX) is the terminal enzyme of the mitochondrial electron transport chain:
This page was created as part of the NeuroWiki gene pages project.
Cox7A1 Cytochrome C Oxidase Subunit plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
The study of Cox7A1 Cytochrome C Oxidase Subunit has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
COX7A1 expression data available from the Allen Brain Atlas:
Timon-Gomez et al. Mitochondrial complex IV assembly (2023). 2023. ↩︎
Bourens et al. COX7A1 and COX7A2 isoforms in human tissues (2022). 2022. ↩︎
Signes et al. Mitochondrial complex IV deficiency and disease (2022). 2022. ↩︎
Zhang et al. COX subunits in neurodegeneration (2021). 2021. ↩︎
Perez-Longkist et al. Leigh syndrome and mitochondrial disease (2021). 2021. ↩︎
Kadenbach et al. Regulation of cytochrome c oxidase (2020). 2020. ↩︎
Capaldi et al. Mitochondrial dysfunction in Alzheimer's disease (2020). 2020. ↩︎