Cox5A Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| COX5A — Cytochrome C Oxidase Subunit 5A | |
|---|---|
| Gene Symbol | COX5A |
| Full Name | Cytochrome C Oxidase Subunit 5A |
| Chromosomal Location | 15q15.3 |
| NCBI Gene ID | [847](https://www.ncbi.nlm.nih.gov/gene/847) |
| Ensembl ID | ENSG00000178741 |
| UniProt ID | [P20674](https://www.uniprot.org/uniprot/P20674) |
| Associated Diseases | [Alzheimer's Disease](/diseases/alzheimers-disease), [Parkinson's Disease](/diseases/parkinsons-disease), [Mitochondrial Complex IV Deficiency](/diseases/mitochondrial-complex-iv-deficiency) |
COX5A encodes cytochrome c oxidase subunit 5A, a crucial component of mitochondrial complex IV (cytochrome c oxidase, COX). Complex IV is the terminal enzyme of the mitochondrial electron transport chain and is responsible for oxidizing cytochrome c and reducing oxygen to water, a process essential for aerobic ATP production.
COX5A is a nuclear-encoded subunit that is imported into mitochondria. It is specifically expressed in tissues with high oxidative metabolism, including:
COX5A is part of the core structure of complex IV:
COX5A expression is particularly high in:
COX5A expression patterns:
Expression is regulated by:
The study of Cox5A Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.