Cnr1 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| Property | Value | [1]
|----------|-------| [2]
| Gene Symbol | CNR1 | [3]
| Full Name | Cannabinoid Receptor 1 | [4]
| Chromosomal Location | 6q25.2 | [5]
| NCBI Gene ID | 1268 | [6]
| OMIM | 114010 | [7]
| Ensembl ID | ENSG00000118432 |
| UniProt ID | P21554 |
| Associated Diseases | Cannabis Use Disorder, Schizophrenia, Parkinson's Disease, Alzheimer's Disease |
The CNR1 gene encodes the cannabinoid receptor type 1 (CB1), a G protein-coupled receptor that is the most abundant cannabinoid receptor in the brain. It is the primary target of Δ9-tetrahydrocannabinol (THC), the psychoactive component of cannabis.
CNR1 is highly expressed in:
The CNR1 gene encodes the CB1 cannabinoid receptor:
CB1 responds to endogenous cannabinoids:
CB1 receptor activation provides neuroprotection through:
The study of Cnr1 Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Di Marzo V. (2008). Endocannabinoid signaling in the brain. 2008. ↩︎
Hurd YL. (2017). Cannabis and the adolescent brain. 2017. ↩︎
Piazza PV, et al. (2020). CNR1 and cannabis addiction. 2020. ↩︎
Fernández-Ruiz J, et al. (2000). Cannabinoid receptors in neurodegeneration. 2000. ↩︎
García-González D, et al. (2019). CB1 and Alzheimer's disease. 2019. ↩︎
Walther S, et al. (2019). Cannabis and psychosis. 2019. ↩︎
Chiarlone A, et al. (2014). CB1 and Parkinson's disease. 2014. ↩︎