Clusterin is a Chaperone protein involved in lipid transport, protein folding, and neurodegeneration. Associated with Alzheimer's disease and other age-related diseases.
title: CLU Gene [1]
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Clu Gene Clusterin is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes. [3]
| Property | Value | [4]
|----------|-------| [5]
| Gene Symbol | CLU |
| Full Name | Clusterin |
| Chr Location | 8p21.1 |
| NCBI Gene ID | 1115 |
| OMIM ID | 185551 |
| Ensembl ID | ENSG00000120885 |
| UniProt ID | P10909 |
| Encoded Protein | Clusterin (ApoJ) |
| Associated Diseases | Alzheimer's disease, Huntington's disease, ALS, frontotemporal dementia |
CLU encodes clusterin, also known as apolipoprotein J (ApoJ), a multifunctional glycoprotein that is highly expressed in the brain. Clusterin participates in various physiological processes including lipid transport, complement regulation, and apoptosis.
Key normal physiological functions include:
The protein has two subunits:
CLU is one of the most significant genetic risk factors for late-onset AD:
Clusterin is widely expressed in the brain:
The Allen Brain Atlas shows high CLU expression in:
The study of Clu Gene Clusterin has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Last et al. Ataxin-2 function and disease (2020). 2020. ↩︎
Sato et al. ATXN2 in Parkinson's disease (2019). 2019. ↩︎
Nonis et al. ATXN2 in diabetes (2022). 2022. ↩︎
Kumar et al. ATXN2 therapeutic targeting (2021). 2021. ↩︎