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| Symbol | CHRNE |
| Full Name | Cholinergic Receptor Nicotinic Epsilon Subunit |
| Chromosome | 17p13.2 |
| NCBI Gene | 1145 |
| OMIM | 100725 |
| Ensembl | ENSG00000108175 |
| UniProt | P30530 |
| Associated Diseases | Myasthenia gravis, congenital myasthenia |
CHRNE (Cholinergic Receptor Nicotinic Alpha Subunit) is a gene encoding a protein that plays important roles in neuronal signaling and has been implicated in neurodegenerative diseases including Alzheimer's and Parkinson's disease.
The CHRNE gene encodes a critical subunit of nicotinic acetylcholine receptors (nAChRs), which are ligand-gated ion channels important for fast synaptic transmission in the central nervous system. These receptors are widely expressed in the brain and play roles in cognitive function, attention, and motor control.
Nicotinic acetylcholine receptors are pentameric ligand-gated ion channels composed of alpha and beta subunits. The CHRNE subunit contributes to receptor heterogeneity and influences receptor trafficking, conductance properties, and pharmacological sensitivity. Research has shown that variations in CHRNE are associated with nicotine dependence, and dysregulation of these receptors has been observed in neurodegenerative conditions.
CHRNE encodes the epsilon subunit of nicotinic acetylcholine receptors. It replaces the gamma (γ) subunit in adult-type receptors at the neuromuscular junction. Mutations cause congenital myasthenic syndromes and postsynaptic congenital myasthenia.
CHRNE encodes the epsilon subunit of nicotinic receptors at the NMJ. Important for synaptic transmission.
Expressed at neuromuscular junction.