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| Symbol | CHRND |
| Full Name | Cholinergic Receptor Nicotinic Delta Subunit |
| Chromosome | 2q37.1 |
| NCBI Gene | 1144 |
| OMIM | 121011 |
| Ensembl | ENSG00000166003 |
| UniProt | P30532 |
| Associated Diseases | Myasthenia gravis, slow channel syndrome |
CHRND (Cholinergic Receptor Nicotinic Alpha Subunit) is a gene encoding a protein that plays important roles in neuronal signaling and has been implicated in neurodegenerative diseases including Alzheimer's and Parkinson's disease.
The CHRND gene encodes a critical subunit of nicotinic acetylcholine receptors (nAChRs), which are ligand-gated ion channels important for fast synaptic transmission in the central nervous system. These receptors are widely expressed in the brain and play roles in cognitive function, attention, and motor control.
Nicotinic acetylcholine receptors are pentameric ligand-gated ion channels composed of alpha and beta subunits. The CHRND subunit contributes to receptor heterogeneity and influences receptor trafficking, conductance properties, and pharmacological sensitivity. Research has shown that variations in CHRND are associated with nicotine dependence, and dysregulation of these receptors has been observed in neurodegenerative conditions.
CHRND encodes the delta subunit of nicotinic acetylcholine receptors. This subunit is essential for proper receptor assembly and function at the neuromuscular junction. Mutations in CHRND can lead to congenital myasthenic syndromes and are associated with slow-channel syndrome.
CHRND encodes the delta subunit of nicotinic receptors. Essential for receptor assembly.
Expressed at neuromuscular junction.