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| Symbol | CHRNA6 |
| Full Name | Cholinergic Receptor Nicotinic Alpha Subunit 6 |
| Chromosome | 8p21 |
| NCBI Gene | 121601 |
| OMIM | 118512 |
| Ensembl | ENSG00000147454 |
| UniProt | P31415 |
| Associated Diseases | Nicotine addiction, movement disorders |
CHRNA6 (Cholinergic Receptor Nicotinic Alpha Subunit) is a gene encoding a protein that plays important roles in neuronal signaling and has been implicated in neurodegenerative diseases including Alzheimer's and Parkinson's disease.
The CHRNA6 gene encodes a critical subunit of nicotinic acetylcholine receptors (nAChRs), which are ligand-gated ion channels important for fast synaptic transmission in the central nervous system. These receptors are widely expressed in the brain and play roles in cognitive function, attention, and motor control.
Nicotinic acetylcholine receptors are pentameric ligand-gated ion channels composed of alpha and beta subunits. The CHRNA6 subunit contributes to receptor heterogeneity and influences receptor trafficking, conductance properties, and pharmacological sensitivity. Research has shown that variations in CHRNA6 are associated with nicotine dependence, and dysregulation of these receptors has been observed in neurodegenerative conditions.
CHRNA6 encodes the alpha-6 subunit of nicotinic acetylcholine receptors. It is primarily expressed in the substantia nigra and ventral tegmental area, where it plays crucial roles in dopamine release and nicotine addiction. The α6 subunit forms functional receptors with α4 and β2/β3 subunits, making it critical for reward pathways and motor control.
CHRNA6 encodes the alpha-6 subunit of nicotinic receptors. Important for dopamine release and motor control.
Expressed in substantia nigra and VTA.