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| Symbol | CHRM4 |
| Full Name | Cholinergic Receptor Muscarinic 4 |
| Chromosome | 11p12 |
| NCBI Gene | 1130 |
| OMIM | 118550 |
| Ensembl | ENSG00000180720 |
| UniProt | P48193 |
| Associated Diseases | Memory, schizophrenia |
CHRM4 (Cholinergic Receptor Muscarinic 4) is a muscarinic acetylcholine receptor that mediates cholinergic signaling in the central and peripheral nervous systems. Muscarinic receptors are G protein-coupled receptors that regulate various neuronal functions including cognition, memory, and motor control. Dysregulated CHRM4 signaling has been implicated in neurodegenerative diseases including Alzheimer's disease.
CHRM4 encodes the M4 muscarinic acetylcholine receptor. It couples to Gi and inhibits adenylate cyclase. Important for modulating cholinergic signaling.
Expressed in striatum and cortex.