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| Symbol | CHRM3 |
| Full Name | Cholinergic Receptor Muscarinic 3 |
| Chromosome | 1q41 |
| NCBI Gene | 1129 |
| OMIM | 118510 |
| Ensembl | ENSG00000133019 |
| UniProt | P20333 |
| Associated Diseases | Bladder dysfunction, cognitive function |
CHRM3 (Cholinergic Receptor Muscarinic 3) is a muscarinic acetylcholine receptor that mediates cholinergic signaling in the central and peripheral nervous systems. Muscarinic receptors are G protein-coupled receptors that regulate various neuronal functions including cognition, memory, and motor control. Dysregulated CHRM3 signaling has been implicated in neurodegenerative diseases including Alzheimer's disease.
CHRM3 encodes the M3 muscarinic acetylcholine receptor. It mediates smooth muscle contraction and glandular secretion. Also involved in cognitive processes.
Expressed in cortex, hippocampus, and peripheral tissues.