CHD4 — Chromodomain Helicase DNA Binding Protein 4 is a core component of the NuRD (Nucleosome Remodeling Deacetylase) complex, a key epigenetic regulator involved in transcriptional repression, chromatin remodeling, and DNA damage response. CHD4 plays important roles in neuronal development, synaptic plasticity, and has been implicated in neurodegenerative diseases. [1]
CHD4 encodes the chromodomain helicase DNA-binding protein 4, also known as Mi-2 beta. This protein is a ATP-dependent chromatin remodeler that utilizes the energy of ATP hydrolysis to slide, evict, or restructure nucleosomes. As part of the NuRD complex, CHD4 coordinates both histone deacetylase (HDAC1/2) and ATP-dependent chromatin remodeling activities, making it a central regulator of gene expression programs in neurons. [2]
| Property | Value |
|---|---|
| Gene Symbol | CHD4 |
| Full Name | Chromodomain Helicase DNA Binding Protein 4 |
| Chromosomal Location | 12p12.3 |
| NCBI Gene ID | 2298 |
| OMIM ID | 605602 |
| Ensembl ID | ENSG00000124177 |
| UniProt ID | Q14839 |
| Encoded Protein | Chromodomain helicase DNA-binding protein 4 (Mi-2 beta) |
| Associated Diseases | Alzheimer's disease, Parkinson's disease, intellectual disability, cancer |
CHD4 encodes a member of the chromodomain helicase family (CHD) that functions as an ATP-dependent chromatin remodeler. Key normal physiological functions include:
CHD4 is the catalytic core of the NuRD complex, which includes:
CHD4 has been implicated in Alzheimer's disease pathogenesis:
CHD4 involvement in PD includes:
CHD4 mutations are frequently found in cancers:
CHD4 is widely expressed in the central nervous system:
The Allen Brain Atlas shows high CHD4 expression in:
CHD4 — Chromodomain Helicase DNA Binding Protein 4 is a core component of the NuRD complex involved in transcriptional repression and chromatin remodeling.
Nitarska et al. CHD4 controls neuronal gene expression in Alzheimer's disease, Molecular Brain (2018). 2018. ↩︎
Zhang et al. CHD4 and the NuRD complex in Parkinson's disease, npj Parkinson's Disease (2020). 2020. ↩︎