Gene SymbolCD63
Full NameCD63 Antigen (LAMP-3)
Chromosomal Location12q13.2
Ensembl IDENSG00000135404
Associated DiseasesCancer, Neurodegeneration
The CD63 gene encodes CD63 antigen, also known as lysosome-associated membrane protein 3 (LAMP-3). CD63 is a member of the tetraspanin family and is involved in various cellular processes including membrane trafficking, cell adhesion, and signal transduction [1].
CD63 is expressed on the surface of various cell types and is particularly abundant in intracellular vesicles, including lysosomes and endosomes. It plays a role in platelet activation, tumor cell migration, and immune responses [2].
CD63 functions as:
- Membrane Trafficking: Regulates vesicular trafficking and endosomal sorting
- Cell Adhesion: Modulates integrin-mediated cell adhesion
- Platelet Activation: Marker of platelet activation
- Immune Response: Involved in immune cell function
- Tumor Progression: Associated with cancer metastasis
- Cancer: CD63 expression correlates with tumor progression and metastasis
- Neurodegeneration: Altered expression in certain neurodegenerative conditions
- Bleeding Disorders: Platelet CD63 as a marker
- Platelets: High expression, used as activation marker
- Immune cells: Monocytes, neutrophils, lymphocytes
- Endothelial cells: Variable expression
- Brain: Neurons and glia
- NCBI Gene: CD63
- UniProt: CD63