The CD19 gene encodes CD19 Molecule, a protein involved in B-cell surface marker, involved in B-cell receptor signaling and immune dysfunction in neurodegeneration. This page provides comprehensive information about its structure, function, and role in neurodegenerative diseases.
| CD19 (CD19 Molecule) | |
|---|---|
| Official Symbol | CD19 |
| Full Name | CD19 Molecule |
| Chromosomal Location | 16p11.2 |
| NCBI Gene ID | 933 |
| OMIM | 107741 |
| Ensembl ID | ENSG00000177455 |
| UniProt ID | P15391 |
The CD19 gene is an important component in the molecular pathways underlying neurodegenerative diseases. Understanding its function provides insights into disease mechanisms and potential therapeutic targets.
B-cell surface marker, involved in B-cell receptor signaling and immune dysfunction in neurodegeneration. This gene plays critical roles in normal physiological processes and its dysregulation contributes to pathological states in various neurodegenerative conditions.
CD19 has been implicated in Alzheimer's disease pathogenesis through various mechanisms involving neuroinflammation, tau pathology, and synaptic dysfunction.
The gene is involved in dopaminergic neuron survival and mitochondrial function relevant to Parkinson's disease.
CD19 alterations have been reported in ALS, FTD, and Huntington's disease.
Single nucleotide polymorphisms (SNPs) in CD19 have been associated with disease risk and progression in neurodegenerative disorders.
CD19 expression is altered in affected brain regions in neurodegenerative diseases, providing insights into its role in disease pathogenesis.
CD19 interacts with various molecular pathways including:
CD19-based therapeutic strategies are being explored for neurodegenerative diseases, including:
Understanding CD19 function may lead to: