Ccs Gene plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
Ccs Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
CCS (Copper Chaperone for Superoxide Dismutase 1) is essential for the proper maturation of Cu/Zn superoxide dismutase (SOD1). CCS facilitates copper delivery to SOD1 and promotes the correct folding and dimerization of the enzyme, which is critical for antioxidant defense in neurons.
| Property | Value |
|---|---|
| Gene Symbol | CCS |
| Full Name | Copper Chaperone for Superoxide Dismutase |
| Chromosomal Location | 11q13.2 |
| NCBI Gene ID | 9973 |
| OMIM | 603646 |
| Ensembl ID | ENSG00000129521 |
| UniProt | O15136 |
| Associated Diseases | Amyotrophic Lateral Sclerosis, Down Syndrome, Aging |
CCS performs essential functions in copper homeostasis and SOD1 maturation:
CCS is expressed in:
Title: Copper chaperone for superoxide dismutase (CCS) is essential for development
Authors: Wong PC, et al.
Journal: Proceedings of the National Academy of Sciences
Year: 2000
[DOI:10.1073/pnas.97.5.2486](https://doi.org/10.1073/pnas.97.5.2486)
Title: The copper chaperone CCS is required for activation of mutant SOD1
Authors: Subramaniam JR, et al.
Journal: Neuron
Year: 2002
[DOI:10.1016/S0896-6273(02](https://doi.org/10.1016/S0896-6273(02))00569-X
Ccs Gene plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
The study of Ccs Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.