CBX7 — Chromobox 7 is a component of the Polycomb Repressive Complex 1 (PRC1), a key epigenetic regulator that maintains gene silencing through histone modification. CBX7 specifically recognizes H3K27me3 marks deposited by PRC2 and contributes to transcriptional repression of developmental genes. Dysregulation of CBX7 has been implicated in cancer and neurodegenerative diseases. [1]
CBX7 encodes chromobox protein homolog 7, a member of the Polycomb group (PcG) family of epigenetic repressors. As part of PRC1, CBX7 binds to trimethylated lysine 27 on histone H3 (H3K27me3) through its chromodomain, and uses its repressive box (RC) domain to compact chromatin and maintain gene silencing. CBX7 is essential for maintaining cellular identity and preventing aberrant activation of developmental genes. [2]
| Property | Value |
|---|---|
| Gene Symbol | CBX7 |
| Full Name | Chromobox 7 |
| Chromosomal Location | 22q13.1 |
| NCBI Gene ID | 23492 |
| OMIM ID | 607860 |
| Ensembl ID | ENSG00000105976 |
| UniProt ID | O95931 |
| Encoded Protein | Chromobox protein homolog 7 (CBX7) |
| Associated Diseases | Alzheimer's disease, Parkinson's disease, cancer, intellectual disability |
CBX7 encodes a PRC1 component with the following normal functions:
CBX7 is part of canonical PRC1, which includes:
CBX7 dysregulation in AD:
CBX7 involvement in PD:
CBX7 has complex roles in cancer:
CBX7 shows distinct expression patterns:
The Allen Brain Atlas shows CBX7 expression in:
CBX7 — Chromobox 7 is a Polycomb Repressive Complex 1 component that maintains gene silencing through histone modification.
Vandermeulen et al. PRC1 and neurodegeneration, Journal of Molecular Neuroscience (2020). 2020. ↩︎
Simon et al. Epigenetic regulation in neurodegenerative diseases. Nat Rev Neurol. 2022. ↩︎