Calb2 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
:: infobox .infobox-gene [1]
Symbol: CALB2 [2]
Full Name: Calretinin [3]
Chromosomal Location: 16q22.2 [4]
NCBI Gene ID: 794 [5]
OMIM: 114105 [6]
Ensembl ID: ENSG00000171331 [7]
UniProt: P22676
Proteins: Calretinin
Associated Diseases: Alzheimer's Disease, Schizophrenia, Mesial Temporal Sclerosis
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CALB2 is a gene/protein encoding a key neuronal protein involved in synaptic function, signal transduction, and cellular homeostasis. Dysfunction of CALB2 is associated with neurodegenerative diseases including Alzheimer's disease, Parkinson's disease, and related disorders.
CALB2 encodes calretinin, a calcium-binding protein of the EF-hand family. Calretinin is expressed in specific neuronal populations and is considered a neuroprotective molecule due to its calcium-buffering capacity. It is used as a marker for certain interneuron subtypes and is altered in various neurological disorders.
Calretinin is expressed in:
Distinct expression pattern from calbindin marks different neuronal populations.
The study of Calb2 Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
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Rozycka A, Liguz-Lecznar M. "The space where aging acts: focus on the GABAergic synapse." Aging cell (2017). Aging cell. 2017. ↩︎
Matthews EA et al. "RNA-programmable cell-type monitoring and manipulation in the human cortex with CellREADR." Cell reports (2025). Cell reports. 2025. ↩︎
Wong NF et al. "Convergence of Type 1 Spiral Ganglion Neuron Subtypes onto Principal Neurons of the Anteroventral Cochlear Nucleus." J Neurosci (2025). J Neurosci. 2025. ↩︎
Maksimova MA et al. "Interneuron Functional Diversity in the Mouse Accessory Olfactory Bulb." eNeuro (2019). eNeuro. 2019. ↩︎
Navarro-Gonzalez C et al. "Nrg1 haploinsufficiency alters inhibitory cortical circuits." Neurobiology of disease (2021). Neurobiology of disease. 2021. ↩︎
Al-Jaberi N et al. "The early fetal development of human neocortical GABAergic interneurons." *Cerebral cortex (New York, N.Y. Cerebral cortex (New York, N.Y. : 1991). 1991. ↩︎