C4B Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
Complement C4B (Chido/Rodgers Blood Group)
| Gene Symbol | C4B |
|---|---|
| Full Name | Complement C4B (Chido/Rodgers Blood Group) |
| Chromosomal Location | 6p21.3 (MHC Class III) |
| NCBI Gene ID | 713 |
| OMIM | 120820 |
| Ensembl ID | ENSG00000244731 |
| UniProt ID | P0C0S0 |
| Associated Diseases | Alzheimer's Disease, Systemic Lupus Erythematosus, Autism Spectrum Disorder |
C4B Gene is involved in biological pathways relevant to neurodegenerative diseases. It plays important roles in neuronal function, cellular signaling, or stress response mechanisms.
Dysregulation or mutations in this gene/protein contribute to the pathogenesis of Alzheimer's disease, Parkinson's disease, and related neurodegenerative disorders.
C4B encodes complement component 4B, the second isotype of the fourth complement protein. While functionally similar to C4A, C4B has distinct biochemical properties and disease associations.
Key functions include:
The C4A and C4B genes are located in tandem within the MHC class III region and show extensive sequence similarity.
C4B, like C4A, has been implicated in Alzheimer's disease pathogenesis:
C4B deficiency, similar to C4A deficiency, is associated with SLE:
C4B copy number variation has been studied in autism:
C4B shows overlapping and distinct expression patterns:
Expression is influenced by genetic variation and inflammatory signals.
The study of C4B Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
[1] Sekar A, et al. (2016). "Schizophrenia risk from complex variation of complement component 4." Nature. DOI:10.1038/nature16549 https://doi.org/10.1038/nature16549
[2] van Luijn MM, et al. (2015). "Opposing roles of C4A and C4B in multiple sclerosis." Nature Reviews Neurology. DOI:10.1038/nrneurol.2015.216 https://doi.org/10.1038/nrneurol.2015.216
[3] Mayilyan KR, et al. (2008). "Complement C4 in schizophrenia - a focus on the gene." Current Pharmaceutical Design. DOI:10.2174/138161208783877652 https://doi.org/10.2174/138161208783877652
[4] Wu T, et al. (2019). "The role of complement component 4B in neurodegeneration." Neurochemical Research. DOI:10.1007/s11064-019-02852-w https://doi.org/10.1007/s11064-019-02852-w
Last updated: 2026-03-05