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| Symbol | ATP2B3 |
| Full Name | ATPase Plasma Membrane Ca2+ Transporting 3 |
| Chromosome | Xq28 |
| NCBI Gene | 493 |
| OMIM | 300074 |
| Ensembl | ENSG00000141314 |
| UniProt | P32010 |
| Associated Diseases | X-linked deafness |
ATP2B3 is a gene encoding a protein involved in ion transport that plays important roles in neuronal function and has been implicated in neurodegenerative diseases.
The ATP2B3 gene encodes a protein that is part of a family of ion transporters critical for maintaining ionic homeostasis in neurons. These proteins are essential for proper neuronal excitability, calcium signaling, and cellular viability.
Ion transporters maintain the electrochemical gradients necessary for neuronal function. The ATP2B3 protein contributes to cellular homeostasis and has been studied in the context of excitotoxicity, calcium dysregulation, and neurodegenerative processes in Alzheimer's and Parkinson's disease.
ATP2B3 encodes PMCA3, primarily expressed in the brain and testis. It contributes to neuronal calcium homeostasis and is important for synaptic function.
ATP2B3 (PMCA3) is a plasma membrane calcium ATPase. Important for neuronal calcium homeostasis.
Expressed in brain.