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| Symbol | ATP2A3 |
| Full Name | ATPase Sarcoplasmic/Endoplasmic Reticulum Ca2+ Transporting 3 |
| Chromosome | 7p15.3 |
| NCBI Gene | 489 |
| OMIM | 602496 |
| Ensembl | ENSG00000108654 |
| UniProt | Q9UMR3 |
| Associated Diseases | Cancer, platelet function |
ATP2A3 is a gene encoding a protein involved in ion transport that plays important roles in neuronal function and has been implicated in neurodegenerative diseases.
The ATP2A3 gene encodes a protein that is part of a family of ion transporters critical for maintaining ionic homeostasis in neurons. These proteins are essential for proper neuronal excitability, calcium signaling, and cellular viability.
Ion transporters maintain the electrochemical gradients necessary for neuronal function. The ATP2A3 protein contributes to cellular homeostasis and has been studied in the context of excitotoxicity, calcium dysregulation, and neurodegenerative processes in Alzheimer's and Parkinson's disease.
ATP2A3 encodes SERCA3, a calcium ATPase isoform expressed in various tissues including the brain. It plays roles in calcium signaling and is implicated in neurodegeneration.
ATP2A3 (SERCA3) is a calcium ATPase with diverse tissue distribution.
Expressed in various tissues.