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| Symbol | ATP2A2 |
| Full Name | ATPase Sarcoplasmic/Endoplasmic Reticulum Ca2+ Transporting 2 |
| Chromosome | 12q24.11 |
| NCBI Gene | 488 |
| OMIM | 108740 |
| Ensembl | ENSG00000174444 |
| UniProt | Q93014 |
| Associated Diseases | Darier disease, neuropsychiatric disorders |
ATP2A2 is a gene encoding a protein involved in ion transport that plays important roles in neuronal function and has been implicated in neurodegenerative diseases.
The ATP2A2 gene encodes a protein that is part of a family of ion transporters critical for maintaining ionic homeostasis in neurons. These proteins are essential for proper neuronal excitability, calcium signaling, and cellular viability.
Ion transporters maintain the electrochemical gradients necessary for neuronal function. The ATP2A2 protein contributes to cellular homeostasis and has been studied in the context of excitotoxicity, calcium dysregulation, and neurodegenerative processes in Alzheimer's and Parkinson's disease.
ATP2A2 encodes SERCA2, a calcium ATPase expressed in cardiac and skeletal muscle as well as neurons. It is crucial for calcium homeostasis and mutations cause Darier disease.
ATP2A2 (SERCA2) is a calcium ATPase important for calcium homeostasis in ER. Mutations cause skin and neurological disorders.
Widely expressed.