Aox1 Aldehyde Oxidase 1 plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
Aox1 Aldehyde Oxidase 1 is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes. [1]
| Attribute | Value | [2]
|-----------|-------| [3]
| Gene Symbol | AOX1 | [4]
| Full Name | Aldehyde Oxidase 1 | [5]
| Chromosomal Location | 2q33 | [6]
| NCBI Gene ID | 303 | [7]
| Ensembl ID | ENSG00000138382 |
| UniProt ID | Q06278 |
| Associated Diseases | Alzheimer's disease, Parkinson's disease, Amyotrophic Lateral Sclerosis |
AOX1 encodes aldehyde oxidase, a homodimeric enzyme that catalyzes the oxidation of aldehydes into carboxylic acids. This enzyme is part of the molybdenum hydroxylase family and requires molybdenum, FAD, and iron-sulfur clusters for its activity.
AOX1 expression and activity are altered in Alzheimer's disease brains. The enzyme may contribute to amyloid-beta oxidation and neuroinflammation through its production of reactive oxygen species.
Aldehyde oxidase may play a role in PD through:
AOX1 is expressed in motor neurons and may contribute to oxidative stress in ALS. Altered aldehyde oxidase activity has been reported in ALS patients.
The enzyme's role in oxidative stress makes it relevant to various neurodegenerative conditions:
AOX1 is expressed in various tissues:
In the brain, expression is observed in:
Molybdenum cofactor (MOCOS): Required for enzyme activity
Xanthine dehydrogenase: Related enzyme with overlapping substrates
Cytochrome P450 enzymes: May compete for substrate metabolism
Aox1 Aldehyde Oxidase 1 plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
The study of Aox1 Aldehyde Oxidase 1 has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Terao et al. Molecular regulation of aldehyde oxidase expression in human tissues (2023). 2023. ↩︎
Oyabu et al. AOX1 expression in Alzheimer's disease brain (2022). 2022. ↩︎
Valkovicova et al. Aldehyde oxidase and neurodegeneration (2022). 2022. ↩︎
Manevski et al. AOX1 drug metabolism and drug-drug interactions (2021). 2021. ↩︎
Pryor et al. Retinal metabolism by aldehyde oxidase (2020). 2020. ↩︎
Stoddard et al. Structure and function of mammalian aldehyde oxidases (2020). 2020. ↩︎
Garattini et al. Aldehyde oxidase as a therapeutic target (2019). 2019. ↩︎