Ager Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
AGER encodes RAGE (Receptor for Advanced Glycation End Products), a pattern recognition receptor involved in inflammation and neurodegeneration. [1]
| Property | Value | [2]
|----------|-------|
| Gene Symbol | AGER |
| Protein Name | RAGE |
| Chromosome | 6p21.3 |
| UniProt ID | Q15120 |
| NCBI Gene ID | 177 |
| OMIM | 600841 |
RAGE is a multi-ligand receptor that binds:
| Approach | Status |
|---|---|
| Anti-RAGE antibodies | Preclinical |
| RAGE inhibitors | Phase 2 trials |
| Decoy receptors | Research |
The RAGE receptor exists in multiple isoforms:
| Isoform | Description | Expression |
|---|---|---|
| Full-length RAGE | Membrane-bound, signaling competent | Various tissues |
| Soluble RAGE (sRAGE) | Decoy receptor, secreted | Detectable in plasma/CSF |
| N-truncated RAGE | Lacks transmembrane domain | Alternative splicing |
The extracellular domain contains one V-type (variable) domain and two C-type (constant) domains, responsible for ligand binding.
RAGE activates multiple downstream signaling cascades:
Several AGER polymorphisms have been associated with disease risk:
RAGE-related biomarkers for neurodegenerative diseases:
The study of Ager Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Srikanth V, et al. (2011) "RAGE and Alzheimer's disease." Journal of Alzheimer's Disease. Journal of Alzheimer's Disease. 2011. ↩︎
Casserly I, Topol E (2004) "Convergence of atherosclerosis and Alzheimer's disease." Lancet. Lancet. 2004. ↩︎