Adcy9 — Adenylate Cyclase 9 is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| Adenylate Cyclase 9 | |
|---|---|
| Gene Symbol | ADCY9 |
| Full Name | Adenylate cyclase 9 |
| Chromosome | 16p13.3 |
| NCBI Gene ID | 116 |
| OMIM | |
| Ensembl ID | ENSG00000100105 |
| UniProt ID | O60344 |
| Associated Diseases | Asthma, Alzheimer's Disease |
ADCY9 (Adenylate Cyclase 9) is a calcium-inhibitable adenylate cyclase isoform that generates cyclic AMP (cAMP) in response to G protein-coupled receptor activation. ADCY9 is expressed in various tissues including brain, heart, and platelets. In neurons, ADCY9 contributes to cAMP-mediated signaling pathways involved in learning, memory, and neuroprotection. ADCY9 is a target of certain pharmaceuticals and its modulation may have therapeutic potential in神经系统 disorders.
ADCY9 encodes adenylate cyclase 9, a calcium/calmodulin-activated adenylyl cyclase. It is expressed in brain and various peripheral tissues. ADCY9 produces cAMP in response to calcium signaling.
Expressed in brain and lung. Important for calcium-dependent cAMP production.
| Disease | Variants | Inheritance | Mechanism |
|---|---|---|---|
| Asthma | Risk variants | Complex | Airway inflammation |
| Alzheimer's Disease | Risk variants | Complex | Calcium-cAMP cross-talk |
The study of Adcy9 — Adenylate Cyclase 9 has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.