Adcy3 — Adenylate Cyclase 3 is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| Adenylate Cyclase 3 | |
|---|---|
| Gene Symbol | ADCY3 |
| Full Name | Adenylate cyclase 3 |
| Chromosome | 2p23.3 |
| NCBI Gene ID | 109 |
| OMIM | |
| Ensembl ID | ENSG00000138031 |
| UniProt ID | O60236 |
| Associated Diseases | Obesity, Alzheimer's Disease |
ADCY3 (Adenylate Cyclase 3) is a widely expressed adenylate cyclase isoform that generates cyclic AMP (cAMP) in response to G protein-coupled receptor activation. ADCY3 is enriched in olfactory epithelium and brain regions involved in energy homeostasis and reward processing. In the central nervous system, ADCY3 plays roles in dopaminergic signaling, feeding behavior, and circadian rhythm regulation. Genetic variants in ADCY3 are associated with obesity and neuropsychiatric disorders, highlighting its importance in metabolic and neurological function.
ADCY3 encodes adenylate cyclase 3, a widely expressed membrane-bound adenylyl cyclase. It is activated by G proteins and calcium/calmodulin. ADCY3 plays important roles in sensory transduction, metabolism, and neuronal signaling.
Expressed in brain (olfactory epithelium, hypothalamus) and peripheral tissues. Important for odor detection and energy homeostasis.
| Disease | Variants | Inheritance | Mechanism |
|---|---|---|---|
| Obesity | Risk variants | Complex | Energy balance dysregulation |
| Alzheimer's Disease | Risk variants | Complex | cAMP signaling impairment |
The study of Adcy3 — Adenylate Cyclase 3 has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.