| Gene Symbol | SIGLEC1 |
|---|---|
| Full Name | Sialic Acid Binding Ig Like Lectin 1 |
| Chromosomal Location | 20p12.1 |
| NCBI Gene ID | [https://www.ncbi.nlm.nih.gov/gene/6614 SIGLEC1] |
| OMIM | [https://www.omim.org/entry/600738 600738] |
| Ensembl ID | ENSG00000105550 |
| UniProt ID | [https://www.uniprot.org/uniprot/Q9PMN3 Q9PMN3] |
| Associated Diseases | Alzheimer's Disease (AD), Multiple Sclerosis (MS), Neuroinflammation |
SIGLEC1 (Sialic Acid Binding Ig Like Lectin 1), also known as CD169 or Sialoadhesin, is a surface receptor primarily expressed on myeloid cells. This gene encodes a member of the siglec family, a group of sialic acid-binding lectins that play crucial roles in immune regulation and cell-cell interactions 1.
SIGLEC1 is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes. The protein is characterized by its ability to recognize and bind to sialylated glycans on the surface of other cells, making it a key player in immune surveillance and inflammatory responses.
SIGLEC1 is a member of the siglec family of sialic acid-binding lectins:
SIGLEC1 transduces signals through its cytoplasmic tail containing immunoreceptor tyrosine-based inhibition motifs (ITIMs). Upon ligand binding, these ITIMs recruit phosphatases like SHP-1 and SHP-2, leading to modulation of immune cell activation thresholds.
SIGLEC1 is upregulated in AD brain:
SIGLEC1 expression correlates with disease activity:
Broad role in CNS inflammatory conditions:
SIGLEC1 expression is primarily on immune cells:
Limited expression in healthy brain; strongly upregulated in disease states.
SIGLEC1 represents a potential therapeutic target:
The study of Siglec1 Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.