Ntf4 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
.infobox .infobox-gene
| Gene Symbol | NTF4 |
|---|---|
| Gene Name | Neurotrophin 4 |
| Chromosome | 19q13.33 |
| NCBI Gene ID | 4909 |
| OMIM ID | 162660 |
| Ensembl ID | ENSG00000126733 |
| UniProt ID | P34130 |
| Associated Diseases | Alzheimer's Disease, Glaucoma |
| --- | --- |
| Categories | Neurotrophin Signaling, Neuroprotection |
This section provides a comprehensive overview of the gene/protein and its role in the nervous system and neurodegenerative diseases.
Neurotrophin-4 (NT-4) is a neurotrophic factor that binds primarily to TrkB (NTRK2) receptors. While less studied than BDNF, NT-4 plays important roles in neuronal survival, synaptic function, and peripheral nerve regeneration. NT-4 has been investigated as a potential therapeutic agent for neurodegenerative diseases and glaucoma.
The NTF4 gene is associated with several neurodegenerative and neurological disorders. Specific mutations cause distinct clinical phenotypes, and common variants may influence disease risk.
The study of Ntf4 Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.