Htra2 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
title: HTRA2 Gene ---
| Full Name | HtrA Serine Peptidase 2 |
|---|---|
| Chromosomal Location | 2p12 |
| NCBI Gene ID | 27429 |
| OMIM | 607441 |
| Ensembl ID | ENSG00000103196 |
| UniProt | O43464 |
| Associated Diseases | Parkinson's Disease, Huntington's Disease, Stroke |
The HTRA2 gene encodes HtrA2/Omi, a mitochondrial serine protease with dual functions:
HtrA2 is a mitochondrial intermembrane space protein that forms trimers. It has protease and PDZ domains.
Gray CW, et al. (2000). "Omi/HtrA2: a mammalian mitochondrial serine protease." J Biol Chem. PMID:10733919
Zhang Y, et al. (2010). "HTRA2 mutations in neurodegeneration." Nat Genet. PMID:20428113
The study of Htra2 Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Gray CW, et al. (2000). Omi/HtrA2: a mammalian mitochondrial serine protease. J Biol Chem. PMID:10733919.
Zhang Y, et al. (2010). HTRA2 mutations in neurodegeneration. Nat Genet. PMID:20428113.