Camk2A Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
.infobox .infobox-gene
| Gene Symbol | CaMK2A |
|---|---|
| Gene Name | Calcium/Calmodulin-Dependent Protein Kinase II Alpha |
| Chromosome | 5q32 |
| NCBI Gene ID | 815 |
| OMIM ID | 114078 |
| Ensembl ID | ENSG00000110931 |
| UniProt ID | Q9UQM7 |
| Associated Diseases | Alzheimer's Disease, Autism Spectrum Disorder, Learning Disabilities |
| --- | --- |
| Categories | Calcium Signaling, Synaptic Plasticity |
This section provides a comprehensive overview of the gene/protein and its role in the nervous system and neurodegenerative diseases.
CaMK2A is a serine/threonine kinase that is abundant in the brain and critical for synaptic plasticity and learning. Autophosphorylation of CaMK2A converts it to a calcium-independent active form that can phosphorylate AMPA receptor subunits and other synaptic proteins. CaMK2A is essential for long-term potentiation (LTP), and its dysfunction is implicated in Alzheimer's disease and intellectual disabilities.
The CaMK2A gene is associated with several diseases.
The study of Camk2A Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.