| Gene Symbol | CCNF |
|---|---|
| Full Name | Cyclin F |
| Chromosomal Location | 16p13.3 |
| NCBI Gene ID | [https://www.ncbi.nlm.nih.gov/gene/891 CCNF] |
| OMIM | [https://www.omim.org/entry/607059 607059] |
| Ensembl ID | ENSG00000129515 |
| UniProt ID | [https://www.uniprot.org/uniprot/Q8N5M7 Q8N5M7] |
| Associated Diseases | Amyotrophic Lateral Sclerosis (ALS), Frontotemporal Dementia (FTD) |
Ccnf Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
CCNF (Cyclin F) encodes a member of the cyclin family that functions as a substrate recognition component of SCF (Skp1-Cul1-F-box) ubiquitin ligase complexes. CCNF plays a critical role in protein degradation and cell cycle regulation, and is the only F-box cyclin known in mammals1.
--- title: CCNF Gene ---
| Gene Symbol | CCNF |
|---|---|
| Full Name | Cyclin F |
| Chromosomal Location | 16p13.
¶ FunctionCCNF is a member of the F-box protein family that serves as the substrate recognition component of SCF-type ubiquitin ligase complexes. The SCFCCNF complex targets specific proteins for ubiquitination and subsequent degradation by the proteasome. Key functions include: ¶ Cell Cycle Regulation
¶ DNA Damage Response
¶ Protein Quality Control
¶ Iron Metabolism
¶ StructureCCNF has a distinctive structure:
¶ Disease Associations¶ Amyotrophic Lateral Sclerosis (ALS)Mutations in CCNF are associated with familial ALS and frontotemporal dementia (FTD)2:
¶ Frontotemporal Dementia (FTD)CCNF mutations are also linked to FTD3:
¶ Other Associations
¶ ExpressionCCNF is expressed ubiquitously with moderate expression in:
Expression is cell cycle-dependent, with peaks during G1/S transition. In neurons, expression is relatively constant, reflecting its role in protein homeostasis rather than proliferation. ¶ Therapeutic PotentialCCNF represents a promising therapeutic target: ¶ Small Molecule Modulators
¶ Gene Therapy Approaches
¶ Mechanism-Based Strategies
¶ Key Publications
¶ Recent ResearchRecent advances in CCNF research include:
¶ BackgroundThe study of Ccnf Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development. Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions. ¶ See Also
¶ References
¶ Cross-references
¶ External Links |