Atm is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
ATM is a gene/protein encoding a key neuronal protein involved in synaptic function, signal transduction, and cellular homeostasis. Dysfunction of ATM is associated with neurodegenerative diseases including Alzheimer's disease, Parkinson's disease, and related disorders.
ATM is a serine/threonine protein kinase critical for DNA damage response:
- DNA damage sensing: Activates in response to DSBs
- Cell cycle arrest: Halts cell cycle for repair
- DNA repair: Coordinates repair pathways
- Mitochondrial function: Regulates mitochondrial dynamics
- Neuronal survival: Protects neurons from genotoxic stress
- Homozygous ATM mutations cause AT
- Neurodegeneration, immunodeficiency, cancer predisposition
- ATM deficiency linked to PD risk
- Impaired DNA repair in dopaminergic neurons
- Mitochondrial dysfunction
- DNA damage accumulates in AD
- ATM signaling dysregulated
- Ubiquitously expressed
- High in neurons
- Mitochondria and nucleus
- 9050862: ATM in DNA damage response. Cell, 1997.
- 28714940: ATM in neurodegeneration. Nat Rev Neurol, 2017.
The study of Atm has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
- Iyaswamy A et al.. "Fe65-engineered neuronal exosomes encapsulating corynoxine-B ameliorate cognition and pathology of Alzheimer's disease." Signal transduction and targeted therapy (2023). DOI: 10.1038/s41392-023-01657-4 PubMed: 37867176
- Litwin T, Dzieżyc K, Członkowska A. "Wilson disease-treatment perspectives." Annals of translational medicine (2019). DOI: 10.21037/atm.2018.12.09 PubMed: 31179305
- Kanungo S et al.. "Glycogen metabolism and glycogen storage disorders." Annals of translational medicine (2018). DOI: 10.21037/atm.2018.10.59 PubMed: 30740405
- Dusek P, Litwin T, Członkowska A. "Neurologic impairment in Wilson disease." Annals of translational medicine (2019). DOI: 10.21037/atm.2019.02.43 PubMed: 31179301
- Post MA, Lefeber DJ. "Clinical glycomics in the diagnostic laboratory." Annals of translational medicine (2019). DOI: 10.21037/atm.2019.08.74 PubMed: 31656799
- Li J, Wang Q, Wang H. "Autoantibodies detection in anti-N-methyl-D-aspartate receptor encephalitis." Annals of translational medicine (2023). DOI: 10.21037/atm-20-2279 PubMed: 37090042
- Gao YL et al.. "Tau in neurodegenerative disease." Annals of translational medicine (2018). DOI: 10.21037/atm.2018.04.23 PubMed: 29951497
- Jaffe RJ, Dave RS, Byrareddy SN. "Meningeal lymphatics in aging and Alzheimer's disease." Annals of translational medicine (2019). DOI: 10.21037/atm.2019.01.06 PubMed: 31032283