Aif1 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
AIF1 (also known as Iba1 - Ionized calcium-binding adapter molecule 1) is a calcium-binding protein specifically expressed in microglia in the brain. It is widely used as a microglial marker and plays roles in actin reorganization, phagocytosis, and inflammatory responses.
AIF1 is expressed almost exclusively on:
Not expressed on neurons, astrocytes, or oligodendrocytes under normal conditions.
Allograft Inflammatory Factor 1 (AIF1) is a gene involved in neurodegeneration. It plays important roles in various cellular processes.
The study of Aif1 Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
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