| Field |
Value |
| NCT Number |
NCT05820425 |
| Status |
Recruiting |
| Phase |
Not Applicable |
| Sponsor |
University Hospital, Grenoble |
| Study Type |
Observational |
| Conditions |
Parkinson's Disease |
| Outcome Measures |
Local field potential recordings from subthalamic nucleus |
The subthalamic nucleus (STN) is a key node in the basal ganglia circuitry and a primary target for deep brain stimulation (DBS) in Parkinson's disease. Understanding the neurophysiological properties of the STN is crucial for optimizing DBS therapy and understanding disease mechanisms.
Why STN LFPs Matter:
- Oscillatory activity: The STN exhibits pathological oscillatory activity in PD, particularly beta frequency band (13-35 Hz) synchronization
- Biomarker potential: LFP patterns may serve as biomarkers for disease severity and treatment response
- DBS optimization: Understanding LFP patterns can guide optimal stimulation parameter selection
- Network dysfunction: LFP recordings reveal how the basal ganglia network is disrupted in PD
This study aims to characterize the local field potential signatures of the subthalamic nucleus in PD patients, potentially providing insights into:
- Pathophysiological mechanisms of STN dysfunction
- Biomarkers for patient selection and monitoring
- Optimization of neuromodulation strategies
- Design: Observational study
- Procedure: Intraoperative microelectrode recording during DBS surgery
- Data collection: LFP recordings from multiple electrode positions within the STN
Local field potentials will be analyzed for:
- Beta-band power and coherence
- Alpha and theta activity
- Pathological oscillation patterns
- Correlation with clinical symptoms