VMAT2 packages monoamines into synaptic vesicles for neurotransmission.
| Property |
Value |
| Category |
Monoamine Transport |
| Location |
Monoamine neurons |
| Transporter |
VMAT2 (SLC18A2) |
| Substrates |
Dopamine, NE, 5-HT |
- VMAT2: Vesicular transporter
- Proton gradient: Energy source
- H+/monoamine: Antiport
- All monoamine neurons: Dopamine, NE, 5-HT
- Chromaffin cells: Epinephrine
- Platelets: 5-HT storage
- Vesicular packaging: Required for release
- Quantal size: Determines release
- Replenishment: Vesicle recycling
- Sequestration: Into vesicles
- Oxidative stress: Protection
- Toxins: VMAT2 protection
- VMAT2: Genetic variants
- Neuroprotection: VMAT2 enhancer
- Therapeutic: Tetrabenazine
- VMAT2: Amphetamine effects
- VMAT2 inhibitors: Pharmacology
- Therapeutic: Targeting
- Eiden. VMAT2 discovery (1983)
- Miller. VMAT2 in disease (2011)