VGAT packages GABA and glycine into synaptic vesicles.
| Property |
Value |
| Category |
GABAergic Transport |
| Location |
GABAergic neurons |
| Transporter |
VGAT (SLC32A1) |
| Substrates |
GABA, Glycine |
- VGAT: Vesicular GABA transporter
- H+/GABA: Antiport
- Chloride gradient: Energy
- GABA: Primary
- Glycine: Co-transmission
- Beta-alanine: Alternative
- All GABA neurons: Required
- Interneurons: Diverse
- Projection neurons: Some
- Glycinergic: Spinal cord
- Mixed: Brainstem
- Modulation: Vesicular
- Vesicular loading: Required
- Quantal content: Determines
- Release probability: Modulates
- Fast inhibition: GABA, Gly
- Network: Balance
- Motor: Spinal
- VGAT: Mutations
- Inhibition: Reduced
- Therapeutic: Targeting
- Glycine: VGAT in
- Startle disease: Mutations
- Therapeutic: Clonazepam
- McIntire. VGAT discovery (1997)
- Wojcik. VGAT function (2006)