V2 receptors are primarily peripheral but have some CNS expression involved in social behavior.
| Property |
Value |
| Category |
Vasopressin Receptor Neurons |
| Location |
Kidney, Hypothalamus, Limbic |
| Receptor Type |
V2 (AVPR2) |
| Signaling |
Gs-coupled |
- Family: V2 receptors
- G protein: Gs
- cAMP: Increases
- Kidney: Principal cells
- **Hypothalamus': Limited
- **Limbic': Low
- **ADH': Receptor
- **Aquaporin': Insertion
- **Diuresis': Inhibition
- **Social behavior': Possible
- **Memory': Unclear
- **Thermoregulation': Role
- V2: Hyponatremia
- **Tolvaptan': Antagonist
- **Water retention': Treatment
- **V2': Night polyuria
- **Desmopressin': Agonist
- **Therapeutic': Treatment
- Birnbaumer, V2 receptor (1999)
- Kahn, V2 in water balance (2005)