TH is the rate-limiting enzyme in catecholamine synthesis, present in dopaminergic and noradrenergic neurons.
| Property |
Value |
| Category |
Catecholamine Enzyme Neurons |
| Location |
Substantia nigra, VTA, LC |
| Enzyme |
Tyrosine hydroxylase |
| Transmitters |
Dopamine, Norepinephrine |
- TH: Rate-limiting step
- Tetrahydrobiopterin: Cofactor
- Iron: Required
- Phosphorylation: Activation
- Feedback: End product inhibition
- Stress: TH regulation
- Pars compacta: A9 neurons
- Dopamine: Motor control
- Parkinson's: Degeneration
- A10 neurons: Reward
- Projections: Limbic
- Addiction: Vulnerability
- Basal ganglia: Motor control
- Initiation: Movement
- Bradykinesia: TH loss
- VTA: Reward prediction
- Learning: Reinforcement
- Addiction: Drugs of abuse
- TH loss: Diagnostic
- L-DOPA: TH substrate
- Gene therapy: TH delivery
- TH: Genetic variants
- Dopamine: Attention
- Therapeutic: Targeting
- Nagatsu. TH discovery (1964)
- Fitzpatrick. TH structure (1999)