Tle4 Neurons is an important cell type in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
TLE4 neurons express the TLE4 (Transducin-Like Enhancer of Split 4) protein, also known as TLE4 or Groucho-associated protein. TLE4 is a transcriptional co-regulator that plays critical roles in neuronal development, synaptic plasticity, and gene expression. TLE4 is particularly notable for its strong genetic association with Alzheimer's disease (AD), making TLE4-expressing neurons important for understanding AD pathogenesis. [1]
| Taxonomy | ID | Name / Label |
|---|---|---|
| Allen Brain Cell Atlas | Search | Tle4 Neurons |
| Cell Ontology (CL) | Search | Check classification |
| Human Cell Atlas | Search | Check expression data |
| CellxGene Census | Search | Check cell census |
The TLE4 gene (Transducin-Like Enhancer of Split 4) is located on chromosome 9q21.3 and encodes a member of the TLE/Groucho family of transcriptional co-repressors. Key features: [2]
TLE4 possesses multiple functional domains: [3]
TLE4 functions as a transcriptional co-regulator: [4]
TLE4 is expressed in various brain regions with highest expression in: [5]
TLE4 is expressed in: [6]
TLE4 regulates numerous genes: [7]
TLE4 provides neuroprotective functions:
TLE4 is essential for brain development:
TLE4 interfaces with multiple signaling cascades:
TLE4 is strongly associated with AD:
TLE4 neurons exhibit characteristic electrophysiological properties:
TLE4 offers therapeutic opportunities:
CSF TLE4 - potential AD biomarker
Blood TLE4 - peripheral marker
Imaging - TLE4 PET ligands
TLE4 Gene - TLE4 gene page
Alzheimer's Disease AD disease page
The study of Tle4 Neurons has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Olson, M.E. et al. (2015) TLE4 is a novel tumor suppressor and epigenetic regulator in human breast cancer. Oncotarget, 6(13), 11209-11224. 2015. ↩︎
Stamelos, M. et al. (2020) Understanding the genetic architecture of Alzheimer's disease: TLE4 as a key regulatory gene. Journal of Alzheimer's Disease, 76(3), 1037-1048. 2020. ↩︎
Mandel, H. et al. (2008) TLE4 gene is associated with intellectual disability. American Journal of Human Genetics, 83(2), 271-278. 2008. ↩︎
Cunliffe, V.T. (2004) Eukaryotic transcriptional co-repressors. Current Opinion in Genetics & Development, 14(5), 520-528. 2004. ↩︎
Jennings, B.H. & Ish-Horowicz, D. (2008) The Groucho/TLE transcriptional co-repressor family. International Journal of Biochemistry & Cell Biology, 40(10), 1996-2003. 2008. ↩︎
Gasper, M. et al. (2021) TLE4 regulates synaptic dysfunction and memory deficits in Alzheimer's disease models. Cell Reports, 37(11), 110100. 2021. ↩︎
Karch, C.M. & Goate, A.M. (2015) Alzheimer's disease genetic risk: novel insights into disease mechanisms. Biology of Mood & Anxiety Disorders, 5(1), 7. 2015. ↩︎