Spinothalamic Tract (Stt) Expanded is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
The Spinothalamic Tract (STT) is a major ascending pain pathway carrying nociceptive and thermal information from the spinal cord to the thalamus. Degeneration of this tract occurs in various neurodegenerative conditions. [1]
| Property | Value | [2]
|----------|-------| [3]
| Category | Spinal Cord / Pain Pathways | [4]
| Location | Lateral and ventral spinal cord, brainstem to thalamus | [5]
| Function | Pain, temperature, crude touch sensation | [6]
| Diseases | ALS, Multiple System Atrophy, Spinal Cord Injury, Syringomyelia | [7]
| Taxonomy | ID | Name / Label |
|---|---|---|
| Allen Brain Cell Atlas | Search | Spinothalamic Tract (STT) Expanded |
| Cell Ontology (CL) | Search | Check classification |
| Human Cell Atlas | Search | Check expression data |
| CellxGene Census | Search | Check cell census |
The STT has two main components:
The study of Spinothalamic Tract (Stt) Expanded has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
The Spinothalamic Tract (STT) is the major ascending pain pathway, carrying:
These dual pathways explain the multidimensional nature of pain perception.
Alzheimer's Disease's Disease: Pain processing is altered in AD:
Multiple System Atrophy:
Amyotrophic Lateral Sclerosis:
Treede RD. The cortical representation of pain. 2008. ↩︎
Defreyn P. Pain in Alzheimer's Disease's disease. 2000. ↩︎
Ford B. Pain in Parkinson's disease. 2010. ↩︎
Goto F. Pain in multiple system atrophy. 2005. ↩︎
Hug A. Pain perception in ALS. 2010. ↩︎
Moisset X. Neuropathic pain in neurodegenerative diseases. 2016. ↩︎
Chen J. Spinothalamic tract function. 2018. ↩︎