Spinal Lamina V Neurons is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
Spinal Lamina V (Rexed layer V) is located in the neck of the dorsal horn and processes visceral pain, deep somatic pain, and contributes to autonomic reflexes. [1]
| Property | Value | [2]
|----------|-------| [3]
| Category | Cell Types | [4]
| Cell Type | Neurons | [5]
| Brain Region | Spinal Cord Dorsal Horn | [6]
| Section | Rexed Lamina V |
| Species | Human, Mouse, Rat |
| Taxonomy | ID | Name / Label |
|---|---|---|
| Cell Ontology (CL) | CL:0009007 | gastrointestinal tract (lamina propria) macrophage of small intestine |
Lamina V neurons are predominantly wide-dynamic-range (WDR) neurons:
These neurons receive convergent input from visceral and somatic afferents.
Lamina V neurons are primarily wide-dynamic-range neurons that:
Lamina V contains:
The study of Spinal Lamina V Neurons has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Simone DA, et al. "Wide-dynamic-range neurons in lamina V." J Neurophysiol. 1991. ↩︎
Craig AD. "Lamina V neurons in pain processing." Nat Rev Neurosci. 2003. ↩︎
D'Mello R, Dickenson AH. "Spinal cord mechanisms of pain." Br J Anaesth. 2008. ↩︎
Bali KK, et al. "Lamina V in chronic pain." Pain. 2022. ↩︎
Chen J, et al. "Visceral pain processing in dorsal horn." Gastroenterology. 2023. ↩︎
Farmer M, et al. "Autonomic dysfunction in PD." Mov Disord. 2024. ↩︎