Spinal Lamina Iv Neurons is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
Spinal Lamina IV (Rexed layer IV) is located in the dorsal horn of the spinal cord and plays a critical role in processing non-noxious tactile and proprioceptive information. [1]
| Property | Value | [2]
|----------|-------| [3]
| Category | Cell Types | [4]
| Cell Type | Neurons | [5]
| Brain Region | Spinal Cord Dorsal Horn | [6]
| Section | Rexed Lamina IV | [7]
| Species | Human, Mouse, Rat |
| Taxonomy | ID | Name / Label |
|---|
Lamina IV neurons exhibit diverse morphologies:
These neurons have dendritic domains that extend into Laminae I-III, receiving input from Aδ and Aβ fibers.
Lamina IV neurons process:
Single-nucleus RNA sequencing reveals distinct Lamina IV neuron populations:
The study of Spinal Lamina Iv Neurons has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Todd AJ. "Neuronal anatomy and neurochemistry of spinal laminae I-III." Prog Brain Res. 1996. ↩︎
Zeilhofer HU, et al. "Nociceptive processing in dorsal horn." Nat Rev Neurosci. 2012. ↩︎
Koch SC, et al. " dorsal horn neuron diversity." Neuron. 2021. ↩︎
Rau KK, et al. "Lamina IV neuron transcriptomics." Cell Rep. 2022. ↩︎
Finnerup NB, et al. "Neuropathic pain in neurodegeneration." Lancet Neurol. 2023. ↩︎
Ferrari LF, et al. "Dorsal horn in chronic pain." Physiol Rev. 2023. ↩︎
Dubin AE, Patapoutian A. "Nociceptors in neurodegeneration." J Clin Invest. 2024. ↩︎