Shank Protein Neurons is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
Shank (SHANK1/2/3) Neurons are neurons with high expression of Shank proteins, which are major scaffold proteins in the postsynaptic density. Shank3 is particularly important for excitatory synaptic function.
Shank proteins in:
- Dendritic spines: High density
- Hippocampus: CA1, dentate gyrus
- Cortex: Layer 1-6 pyramidal neurons
- Striatum: Medium spiny neurons
- Cerebellum: Purkinje cells
- Shank1: Predominantly in forebrain
- Shank2: Broad expression
- Shank3: Highest in brain
- ANK repeats: Actin binding
- PDZ domain: Scaffold interactions
- Proline-rich region: Cortactin binding
- SAM domain: Multimerization
- SHANK3 mutations cause Phelan-McDermid syndrome
- Synaptic dysfunction
- Therapeutic: SHANK3 modulators
- Shank3 dysregulation in AD
- Synaptic scaffold changes
- SHANK2/3 associations
- Synaptic pathology
The study of Shank Protein Neurons has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
- Boeckers TM, et al. (2019). Shank proteins in synaptic organization. Cellular and Molecular Life Sciences.
- Jiang YH, et al. (2020). SHANK3 and autism. Nature Reviews Neuroscience.
- Kreitzer AC, et al. (2018). Shank3 and synaptic plasticity. Neuron.
- M雕 RL, et al. (2021). Shank mutations in neurodevelopmental disorders. Molecular Psychiatry.
- Park J, et al. (2019). Shank and dendritic spines. Journal of Neuroscience.
- Sala C, et al. (2018). Shank3 function in synapses. Physiological Reviews.
- Sheng M, et al. (2020). Shank scaffold in disease. Brain Research.
- Zhang L, et al. (2021). Shank in AD and autism. Neurobiology of Disease.